Antiparkinsonian agent, a selective irreversible inhibitor of MAO type b, which is 80% determine MAO activity in the brain and metabolism of dopamine. Rasagiline in 30-80 times more active against MAO-b than MAO type A. it Increases the concentration of dopamine, reduces the formation of toxic free radicals, excessive formation of which is observed in Parkinson's disease. Rasagiline has a neuroprotective effect, in therapeutic doses does not block the metabolism from food of biogenic amines (incl. tiramina), and therefore it does not cause tyramine-induced hypertensive syndrome.
The application is rhinopharyngitis, laryngitis, rinotraheobronhit, otitis media, sinusitis, chronic bronchitis with respiratory failure, bronhospasticski syndrome, bronchial asthma (supportive therapy), respiratory dysfunction in measles, whooping cough, influenza.
2. Poractant alfa
Respiratory distress syndrome in premature newborns weighing more than 700 g.
medication, nonsteroidal anti-inflammatory medication from the group of coxibs. Used to treat osteoarthritis, rheumatoid arthritis, acute pain, painful menstruation and menstrual symptoms, and to reduce the number of polyps of the colon and rectum in patients with familial adenomatous polyposis. The representative of the new generation non-steroidal anti-inflammatory medications — selective COX-2 inhibitors. Selectively disrupts the formation of the prostaglandins involved in the formation of inflammatory reaction and does not affect production of prostaglandins that regulate renal blood flow and the integrity of the mucous membranes of the gastro-intestinal tract. Has a pronounced anti-inflammatory and analgesic effect.
medication for weight loss complex active substance "bupropion + naltrexone". Contrave is used in the therapy involving reduction of caloric content of food taken by the patient and increase physical activity. Both active substances are psychotropic medications, intended for influence on the Central nervous system to ease the patient's psychological state, moved to another system and changed the way of life.
Taufon (taurine) is a sulfur-containing amino acid formed in the body in the process of making zisteina. The medication improves energy metabolism, stimulates reparative processes in degenerative diseases, and contributes to restoration of disturbed metabolism of eye tissues. As sulfur-containing amino acid, the medication normalizes the function of cell membranes, improves metabolic (incl. energy) processes.
Treatment of hyperuricemia in chronic gout.
2. Lesinurad (Zurampic)
The medication is intended for treatment of chronic hyperuricemia. In combination with allopurinol (allopurinol are), an inhibitor of xanthine oxidase, or in combination with febuxostat (febuxostat) medication lisinoril can be administered to treat gout. The medication is a selective inhibitor of reabsorbtsii uric acid. The effect of the medication aimed at blocking the uric acid Transporter URAT1, which increases the excretion of uric acid from the body.
1. Sildenafil citrate
medication for increasing sexual potency.
Antiemetic medication of Central action, a selective antagonist of serotonin 5NT3 receptors. Mainly used to suppress nausea and vomiting resulting from chemotherapy. It acts both at peripheral and Central nervous system, reducing the activity of the vagus nerve that suppresses the gag reflex, and it also blocks the receptors trigger zone of the brain that triggers this reflex.
Indications - neuropathic pain in adults; epilepsy (as adjunctive therapy in adults with partial seizures accompanied or not by secondary generalization); generalized anxiety disorder in adults; fibromyalgia in adults.
Active ingredient levetiracetam is a derivative of piracetam, is not related to existing antiepileptic active components, does not alter normal neurotransmission. The effect of the medication is confirmed in conditions such as focal and epilepsy (epileptiform manifestations / photoparoxysmal reaction).
The Central nervous system stimulants
1. Lisdexamfetamine (Vyvanse)
Psychostimulant used in the attention deficit disorder with hyperactivity in adults and children.
Thrombosis of the vessels
Eculizumab restores the regulation of complement activity in the blood and prevents intravascular hemolysis in patients with paroxysmal nocturnal hemoglobinuria (PNH), and prevents excessive activation of the terminal complement complex in patients with atypical hemolytic uremic syndrome (AHUs), where the disease is genetically determined dysregulation of the complement system. On the other hand, deficiency of terminal complement complex is accompanied by increased incidence of infections by encapsulated microorganisms, mainly meningococcal infection. With eculizumab supports the content of the early products of complement activation that is required for opsonization of microorganisms and elimination of immune complexes.
1. Asfotase alfa (Strensiq)
Asfotase alfa is an enzyme replacement therapy medication to treat a rare disease hypophosphatasia. Hypophosphatasia genetic, chronic and progressive ultra-rare metabolic disease characterized by the mineralization of bones. In this disease the patients are the breakage and deformation of the bones, muscle weakness, convulsions, respiratory failure and not excluded cases of premature death.
1. Sebelipase alfa ((Kanuma)
Sebelius Alfa — recombinant form of the enzyme lysosomal acid lipase. The disease is the accumulation of cholesterol esters (Fig. cholesteryl ester storage disease) or a disease Wolman (eng. Wolman disease) is one of the genetic diseases caused by deficiency of lysosomal acidic lipase. The prevalence of Wolman disease in the world is not more than 1:700 000. The disease is characterized by slow progression, occurs without lesions of the Central nervous system. The age of onset of the disease is from 2 to 23 years. The main symptom is hepatomegaly leading to liver fibrosis. Splenomegaly, liver dysfunction, varicose veins of the esophagus have only some patients. Some patients recurrent abdominal pain, disorders of blood clotting, manifested nasal or gastrointestinal bleeding.
1. Caspofungin (Caspofungin Accord)
Antifungal medication for systemic use. Caspofungin inhibits the synthesis of b-(1,3)-D-glucan is an essential component of the cell wall of many rifamate and yeast. In vitro, caspofungin is active against various pathogenic fungi of the genus Aspergillus and Candida. Caspofungin has excellent activity in the prevention and treatment of pulmonary aspergillosis that identified in research on models of lethal pulmonary infections in vivo.
Лекарственное средство, синтетический глюкокортикостероид, обладающий противовоспалительным и иммунодепрессивным действием наряду со способностью проникать в ЦНС. Благодаря этим свойствам может использоваться при лечении пациентов с отёком мозга и воспалительными заболеваниями глаз (в том числе в сочетании с тобрамицином). Оказывает противовоспалительное, противоаллергическое, десенсибилизирующее, иммунодепрессивное, противошоковое и антитоксическое действие, повышает чувствительность бета-адренорецепторов к эндогенным катехоламинам.
Для применения в офтальмологической практике:
purulent conjunctivitis and allergic, keratitis, keratoconjunctivitis without damaging the epithelium, iritis, iridocyclitis, blepharoconjunctivitis, blepharitis, episcleritis, scleritis, the inflammatory process after eye injuries and surgeries, sympathetic ophthalmia.
For admission into:
acute and subacute thyroiditis, hypothyroidism, progressive ophthalmopathy associated with thyrotoxicosis;
rheumatoid arthritis in the acute phase;
diseases of the connective tissue;
autoimmune hemolytic anemia, thrombocytopenia, aplasia and hypoplasia of hematopoiesis, agranulocytosis, serum sickness;
acute erythroderma, pemphigus (normal), acute eczema (early treatment);
malignant tumors (as an antiemetic in cytostatic treatment);
congenital adrenogenital syndrome;
cerebral edema (usually after preliminary parenteral use of corticosteroids, multiple myeloma, prophylaxis after bone marrow transplantation.
Therapy of osteoarthritis
1. Tanezumab (